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KMID : 1140120110160040348
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Cancer Prevention Research
2011 Volume.16 No. 4 p.348 ~ p.357
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Anti-inflammatory Effects of Sarijang in Lipopolysaccharide-Activated BV2 Microglial Cells
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Park Hye-Young
Choi Yung-Hyun
Choi Eun-A
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Abstract
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Because of chronic microglial activation endangers neuronal survival through the release of various toxic pro-inflammatory molecules, negative regulators of microglial activation have been identified as potential therapeutic candidates in many neurological diseases. In this study, we investigated the inhibitory effects of the sarijang, an aged bamboosalt sauce containing extracts of Rhynchosia nulubilis, sulfur fed duck, Ulmus davidiana roots, and Allium sativum on the production of lipopolysaccharide (LPS)-induced pro- inflammatory mediators in BV2 microglia, such as nitric oxide (NO), prostaglandin E2 (PGE2) and pro-inflammatory cytokines. Sarijang significantly inhibited the excessive production of NO and PGE2 in LPS-stimulated BV2 microglia. It also attenuated expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and pro-inflammatory cytokines such as interleukin-1β(IL-1β) and tumor necrosis factor (TNF)-α. Moreover, sarijang exhibited anti-inflammatory properties by suppressing nuclear factor-kappaB (NF-κB) activation, and downregulating the p38 mitogen-activated protein kinase (MAPK) and extracellular-signal-regulated kinase (ERK) pathways. Our results indicate that sarijang has a potent suppressive effect on the pro-inflammatory responses of activated BV2 microglia. This finding suggests that sarijang may offer substantial therapeutic potential for the treatment of neurodegenerative diseases that are accompanied by microglial activation.
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KEYWORD
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Sarijang, Bamboosalt, Microglia, NO, PGE2, Cytokines
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